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نام علمی دارو
[میدودرین هیدروکلراید-Midodrine Hydrochloride]
گروه دارویی
[داروهای قلبی عروقی]
موارد مصرف میدودرین هیدروکلراید (Midodrine Hydrochloride)
Midodrine hydrochloride tablets are indicated for the treatment of symptomatic orthostatic hypotension (OH). Because Midodrine HCl can cause marked elevation of supine blood pressure (BP >200 mmHg systolic), it should be used in patients whose lives are considerably impaired despite standard clinical care, including non-pharmacologic treatment (such as support stockings), fluid expansion, and lifestyle alterations. The indication is based on Midodrine HCl's effect on increases in 1-minute standing systolic blood pressure, a surrogate marker considered likely to correspond to a clinical benefit. At present, however, clinical benefits of Midodrine HCl, principally improved ability to perform life activities, have not been established. Further clinical trials are underway to verify and describe the clinical benefits of Midodrine HCl.
مکانیسم اثر میدودرین هیدروکلراید (Midodrine Hydrochloride)
Midodrine hydrochloride forms an active metabolite, desglyMidodrine, that is an alpha1-agonist, and exerts its actions via activation of the alpha-adrenergic receptors of the arteriolar and venous vasculature, producing an increase in vascular tone and elevation of blood pressure. DesglyMidodrine does not stimulate cardiac beta-adrenergic receptors. DesglyMidodrine diffuses poorly across the blood-brain barrier, and is therefore not associated with effects on the central nervous system. Administration of Midodrine HCl results in a rise in standing, sitting, and supine systolic and diastolic blood pressure in patients with orthostatic hypotension of various etiologies. Standing systolic blood pressure is elevated by approximately 15 to 30 mmHg at 1 hour after a 10 mg dose of Midodrine, with some effect persisting for 2 to 3 hours. Midodrine HCl has no clinically significant effect on standing or supine pulse rates in patients with autonomic failure.
موارد منع مصرف میدودرین هیدروکلراید (Midodrine Hydrochloride)
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عوارض جانبی میدودرین هیدروکلراید (Midodrine Hydrochloride)
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تداخل دارویی میدودرین هیدروکلراید (Midodrine Hydrochloride)
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مصرف میدودرین هیدروکلراید (Midodrine Hydrochloride) در بارداری
FDA طبقه بندی: C.
مصرف میدودرین هیدروکلراید (Midodrine Hydrochloride) در دوران شیردهی
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مقدار مصرف میدودرین هیدروکلراید (Midodrine Hydrochloride)
برای اطلاع از مقدار و نحوه مصرف دارو با پزشک مشورت کنید.
هشدارها در مورد میدودرین هیدروکلراید (Midodrine Hydrochloride)
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نکات قابل توصیه در مورد میدودرین هیدروکلراید (Midodrine Hydrochloride)
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اَشکال دارویی میدودرین هیدروکلراید (Midodrine Hydrochloride)
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نام تجاری دارو
دارویی یافت نشد.